ODCs

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3 OMIM references -
2 associated genes
No signs/symptoms info

PROTEIN INTERACTIONS: 2

1 OMIM reference -
1 associated gene
10 signs/symptoms

Combined deficiency of factor V and factor VIII

Hereditary cerebral hemorrhage with amyloidosis, Iowa type

LMAN1	(UniProt - OMIM)		APP	(UniProt - OMIM)
MCFD2	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	LMAN1 MCFD2	(0.56) (0.56)	APP APP

Citations in the biomedical literature:

Combined deficiency of factor V and factor VIII		Hereditary cerebral hemorrhage with amyloidosis, Iowa type
	Synonym(s): - F5F8D - FV and FVIII combined deficiency - Familial multiple coagulation factor deficiency		Synonym(s): - HCHWA, Iowa type

	Classification (Orphanet): - Rare genetic disease - Rare hematologic disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease - Rare systemic or rheumatologic disease

	Classification (ICD10): - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism -		Classification (ICD10): (no data available)

	Epidemiological data: Class of prevalence: 1-9 / 1 000 000 Average age onset: variable Average age of death: any age Type of inheritance: autosomal recessive		Epidemiological data: (no data available)

	External references: 3 OMIM references - No MeSH references		External references: 1 OMIM reference - No MeSH references

Hereditary cerebral hemorrhage with amyloidosis, Iowa type
	Very frequent - Abnormal gait - Autosomal dominant inheritance - Cerebral vascular anomalies - Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia - Intracranial / cerebral / meningeal hemorrhage - Myoclonus / fasciculations - Psychic / behavioural troubles - Psychic / psychomotor regression / dementia / intellectual decline - Transient cerebral ischemia / stroke - Troubles of memory / amnesia / hypermnesia
Combined deficiency of factor V and factor VIII
(no data available)